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How exercise protects against consequences of ageing – Research

Recent research revealed that exercise can help you not age faster and protect against the horrifying results of ageing.

Researchers published a paper in the ‘Science Advances Journal’ that revealed that there is an enzyme that is key to why exercise improves our health and protects the body against ageing consequences.

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This discovery has opened up the possibility to manufacture drugs to boost the enzyme’s activity. It may eventually protect your body against the cons of ageing and many other issues like type 2 diabetes.

In the research, it was predicted that the proportion of senior citizens worldwide, i.e. people over 60 years old will double in the next 3 decades. This research originated in Australia. By 2031, more than 6 million Australians will be over 65 years old. An older population means type 2 diabetes is likely to be seen in more individuals. Type 2 diabetes will only increase with an old population worldwide. One of the main reasons that this chronic condition is seen in old people as the development of insulin in their body is slow and also because of the inability of the body to respond to insulin. Insulin generation is slow in the body due to reduced physical activity as we age.

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This concept had been a mystery on how ageing and insulin are connected. Now researchers from Monash University in Australia discovered how physical exercise can enhance insulin responses and promote metabolism. Significantly they have identified an enzyme that is key to this mechanism. This enzyme has the potential to be targeted by drugs to protect against the results of ageing like diabetes and muscle wasting.

The team of researchers from Monash University Biomedicine Discovery Institute led by Prof. Tony Tiganis revealed that reduction in ROS generation during ageing is the main reason for slow insulin development.

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He said that the skeletal muscle constantly produces ROS and this is increased during exercise. “Exercise-induced ROS drives adaptive responses that are integral to the health-promoting effects of exercise,”. The research team also depicted how the enzyme called NOX-4 is important for exercise-induced ROS and the adaptive responses that drive metabolism.

Tiganis further added that the enzyme can be boosted with drugs that can improve insulin development in the body during old age. He also added that there are some elements found naturally that can boost this enzyme like broccoli and cauliflower.

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So, after this interesting insight, are you ready to tie your shoes and go for a walk?

Check out the full research here.

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